Gene information
Official symbol LDLR
Official full name low density lipoprotein receptor
Gene type protein-coding gene
Chromosome19p13.2
Alias symbolLDLCQ2
Gene familyLow density lipoprotein receptors; MicroRNA protein coding host genes
Resources
Entrez Gene 3949
HGNC HGNC:6547
Ensembl ENSG00000130164
Vega OTTHUMG00000171935
UCSC uc002mqk.5
GO terms: 135 records
GO Description Category LogP Number of genes Detail
GO:0001540 amyloid-beta binding GO Molecular Functions -10.7345181 13 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0005041 low-density lipoprotein particle receptor activity GO Molecular Functions -7.91446927 6 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005774 vacuolar membrane GO Cellular Components -1.32038132 10 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0006897 endocytosis GO Biological Processes -8.07395492 24 More
GO:0007586 digestion GO Biological Processes -7.00342423 19 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007613 memory GO Biological Processes -4.31484432 16 More
GO:0007616 long-term memory GO Biological Processes -1.82976708 5 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008203 cholesterol metabolic process GO Biological Processes -19.4799126 22 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0009925 basal plasma membrane GO Cellular Components -3.63700430 11 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0010721 negative regulation of cell development GO Biological Processes -6.74707916 25 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0010984 regulation of lipoprotein particle clearance GO Biological Processes -13.0318362 16 More
GO:0010985 negative regulation of lipoprotein particle clearance GO Biological Processes -8.96527714 10 More
GO:0010988 regulation of low-density lipoprotein particle clearance GO Biological Processes -8.17037988 10 More
GO:0010989 negative regulation of low-density lipoprotein particle clearance GO Biological Processes -8.80074885 9 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014014 negative regulation of gliogenesis GO Biological Processes -4.38480829 9 More
GO:0015748 organophosphate ester transport GO Biological Processes -5.98331847 11 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0015914 phospholipid transport GO Biological Processes -7.60367088 11 More
GO:0015918 sterol transport GO Biological Processes -16.3959877 17 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016125 sterol metabolic process GO Biological Processes -19.5624674 23 More
GO:0016323 basolateral plasma membrane GO Cellular Components -3.38759081 10 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019218 regulation of steroid metabolic process GO Biological Processes -14.2494824 17 More
GO:0022600 digestive system process GO Biological Processes -8.16734280 17 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030136 clathrin-coated vesicle GO Cellular Components -3.00394155 9 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030169 low-density lipoprotein particle binding GO Molecular Functions -10.8464740 8 More
GO:0030228 lipoprotein particle receptor activity GO Molecular Functions -9.05405363 7 More
GO:0030301 cholesterol transport GO Biological Processes -18.3843949 17 More
GO:0030662 coated vesicle membrane GO Cellular Components -3.21530675 9 More
GO:0030665 clathrin-coated vesicle membrane GO Cellular Components -2.98664168 7 More
GO:0030666 endocytic vesicle membrane GO Cellular Components -7.03002758 14 More
GO:0030669 clathrin-coated endocytic vesicle membrane GO Cellular Components -4.62709399 7 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032365 intracellular lipid transport GO Biological Processes -4.08159325 5 More
GO:0032366 intracellular sterol transport GO Biological Processes -5.09468573 5 More
GO:0032367 intracellular cholesterol transport GO Biological Processes -5.51573627 5 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034362 low-density lipoprotein particle GO Cellular Components -6.77353044 5 More
GO:0034381 plasma lipoprotein particle clearance GO Biological Processes -16.8165221 12 More
GO:0034383 low-density lipoprotein particle clearance GO Biological Processes -10.0035192 7 More
GO:0034384 high-density lipoprotein particle clearance GO Biological Processes -8.3287979 5 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0038024 cargo receptor activity GO Molecular Functions -11.0179524 13 More
GO:0042157 lipoprotein metabolic process GO Biological Processes -6.61578697 11 More
GO:0042159 lipoprotein catabolic process GO Biological Processes -3.41433421 5 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045178 basal part of cell GO Cellular Components -4.63395469 13 More
GO:0045334 clathrin-coated endocytic vesicle GO Cellular Components -4.88495680 8 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045685 regulation of glial cell differentiation GO Biological Processes -7.97684638 17 More
GO:0045686 negative regulation of glial cell differentiation GO Biological Processes -3.12309097 6 More
GO:0045732 positive regulation of protein catabolic process GO Biological Processes -6.83749864 15 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0046889 positive regulation of lipid biosynthetic process GO Biological Processes -14.1380112 16 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048710 regulation of astrocyte differentiation GO Biological Processes -5.46031079 9 More
GO:0048844 artery morphogenesis GO Biological Processes -13.4119116 22 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050768 negative regulation of neurogenesis GO Biological Processes -6.01402466 11 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0050892 intestinal absorption GO Biological Processes -7.19451595 7 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051961 negative regulation of nervous system development GO Biological Processes -6.75305746 12 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0055094 response to lipoprotein particle GO Biological Processes -14.9317808 12 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060840 artery development GO Biological Processes -12.7697342 25 More
GO:0061771 response to caloric restriction GO Biological Processes -5.78189015 3 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0070542 response to fatty acid GO Biological Processes -13.2686457 21 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071398 cellular response to fatty acid GO Biological Processes -4.09043632 8 More
GO:0071402 cellular response to lipoprotein particle stimulus GO Biological Processes -16.0665913 13 More
GO:0071404 cellular response to low-density lipoprotein particle stimulus GO Biological Processes -11.9646006 9 More
GO:0071813 lipoprotein particle binding GO Molecular Functions -15.1312842 12 More
GO:0071814 protein-lipid complex binding GO Molecular Functions -15.1312842 12 More
GO:0090181 regulation of cholesterol metabolic process GO Biological Processes -6.71495876 7 More
GO:0090207 regulation of triglyceride metabolic process GO Biological Processes -7.43834818 8 More
GO:0090208 positive regulation of triglyceride metabolic process GO Biological Processes -3.76678874 4 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0097242 amyloid-beta clearance GO Biological Processes -5.57650860 8 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0150079 negative regulation of neuroinflammatory response GO Biological Processes -5.31723275 7 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1902652 secondary alcohol metabolic process GO Biological Processes -19.9585075 23 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902904 negative regulation of supramolecular fiber organization GO Biological Processes -2.83678359 16 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04913 Ovarian steroidogenesis KEGG Pathway -6.83160707 8 More
hsa04925 Aldosterone synthesis and secretion KEGG Pathway -3.76850718 7 More
hsa04927 Cortisol synthesis and secretion KEGG Pathway -2.97866114 5 More
hsa04934 Cushing syndrome KEGG Pathway -3.26102406 8 More
hsa04976 Bile secretion KEGG Pathway -3.16953788 6 More
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
hsa05160 Hepatitis C KEGG Pathway -4.71256920 10 More
Drug-Gene interaction
view
Related drugs: 21 records
Drug name Interaction type Source PMID View
acetylcysteine NCI 12031897 view
alirocumab PharmGKB view
atenolol NCIPharmGKB 15453913 view
atorvastatin PharmGKB view
chembl233611 DTC 17583500 view
cholestyramine NCI 2110363 view
corticotropin NCI 11956163 view
epoetin alfa NCI 9249773 view
evolocumab PharmGKB view
gemfibrozil NCI 9409246 view
glucagon NCI 2552996 view
haloperidol NCI 17052361 view
lomitapide PharmGKB view
lovastatin PharmGKB 16103896 view
mipomersen PharmGKB view
pravastatin PharmGKB view
retinol NCI 2920014 view
ribavirin PharmGKB 21572301 view
tetracycline NCI 9470171 view
tributyrin NCI 16188956 view
verapamil NCI 7683421 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NP_000518.1:p. genomics myocardial infarction[diagnosis] myocardial infarction Thormaehlen AS et al. PLoS Genet. 2015
NM_000527.5:c. genomics myocardial infarction[diagnosis] myocardial infarction Tajima T et al. Sci Rep. 2018
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